The Foxes, third in the Premier League, tackle the Bees, fifth in the Sky Bet Championship, after both sides beat Wigan Athletic and Stoke City respectively in the third round.
Ahead of a first competitive meeting between the two sides in 27 years, LCFC.com continues its series profiling each of Leicester's 2019/20 opponents...
The manager
Danish manager Thomas Frank has been in post at Griffin Park since October 2018 after serving as Dean Smith's assistant before the 48-year-old's departure to Aston Villa, who he later guided to promotion.
After 18 years in youth coaching, working with Frederiksværk, Hvidovre IF, B93, Lyngby and various levels of the Denmark youth set-up, he managed Brøndby IF between 2013 and 2016.
Despite finishing fourth and third successively in the Danish Superliga, Frank's Brøndby side failed to reach the UEFA Europa League group stages, and he resigned from the role in March 2016.
After two years working within the Brentford coaching team, he was promoted to the manager's position in the days following Smith's exit to Villa Park, finishing 11th in the Championship in 2018/19.
This term, Frank's Bees are maintaining a sustained play-off push, leading to a new contract earlier this month, with the London outfit also just five points adrift of second-place Leeds United.
The squad
Just one player among Brentford's squad has been ever-present in the Championship this term, Spanish goalkeeper David Raya, while Ollie Watkins is their top scorer.
Former Exeter City striker Watkins has scored 18 league goals this season, including his first Brentford hat-trick in a 3-1 win over Barnsley in September.
France Under-21s winger Bryan Mbeumo, on the other hand, has found the net on 11 occasions during a season in which only West Bromwich Albion and Queens Park Rangers have scored more.
Summer signings included former Leeds United defender Pontus Jansson, who has appeared 17 times, while midfielder Christian Nørgaard also joined from Fiorentina.
This month, meanwhile, Halil Dervişoğlu headed to Griffin Park from Sparta Rotterdam and midfield man Paris Maghoma also arrived from Tottenham Hotspur.
The trophy cabinet
Brentford lifted the old Second Division title in 1935 before going on to secure their all-time best league finish in the top tier - fifth place - the following season.
They have also won the third division on two occasions, most recently in 1992, while finishing runners up on four occasions, lastly in 2014.
Three fourth division titles included on Brentford's honours list, too. In cup competitions, the Bees have reached the quarter-finals four times and been beaten EFL Trophy finalists on three occasions.
The stadium
Brentford's 116-year stay at Griffin Park - 12,300-capacity venue in Middlesex - is set to come to a close in the summer when the club moves to the Brentford Community Stadium.
Based in a residential area and famously the home of a pub on each corner of the ground, Griffin Park's record attendance, 38,678, was in fact an FA Cup Sixth Round tie against Leicester in 1949.
When the Bees move to their new home, a state-of-the-art venue in west London, they will be the owners of a 17,800-seater stadium, alongside fellow tenants London Irish.
The fixtures
Following Saturday's Emirates FA Cup clash with City, Brentford host promotion rivals Nottingham Forest at Griffin Park on Tuesday, before travelling to Hull City on Saturday.
Thomas Frank's side, meanwhile, head into this weekend's Leicester clash on the back of two wins in their last three games - comfortable successes over Bristol City and Queens Park Rangers.
Earlier in the FA Cup, a solitary goal from Emiliano Marcondes secured a 1-0 victory against Stoke City, setting up Saturday's encounter with Brendan Rodgers' high-flying Foxes.