Just under a year after last facing the Bees, the Foxes make their first-ever visit to the new Brentford Community Stadium hoping to reach the fifth round of the competition.
Ahead of that encounter in the capital, LCFC.com delivers everything you need to know...
How can I watch the game?
Supporters in the United Kingdom will be able to watch the match unfold on BT Sport 1, with the programme starting at 2pm.
Who's starring on LCFC TV?
From 1pm, Matchday Live goes to air on the Club's official website and @LCFC social media, with presenter Dan Bates being joined by former Leicester stars Gerry Taggart and Iwan Roberts.
Then, from approximately 2:20pm, live commentary is provided by LCFC Radio as ex-City captain Matt Elliott accompanies commentator James Fielden in the capital to talk you through the action.
Once the full-time whistle blows, meanwhile, check back to the Club's official Facebook and Twitter feeds for half an hour of reaction from Taggart, Roberts and Elliott, plus post-match interviews.
All pre and post-match coverage is available to access from Leicester City's social media channels, while match commentary can be found on the dedicated LCFC.com Match Centre (free sign-up required).
What's the officiating team?
Referee Michael Oliver will oversee matters at Brentford Community Stadium, assisted by Stuart Burt and Simon Bennett. The fourth official, meanwhile, will be Darren England.
When does everything happen?
Ahead of Leicester's second cup clash against second-tier opposition of the season, this is when everything happens...
| Event | Time |
| Matchday Live begins on LCFC TV | 1pm |
| Team news confirmed on LCFC social | 1:30pm |
| BT Sport coverage commences* | 2pm |
| Commentary starts on LCFC Radio | 2:20pm |
| Kick-off | 2:30pm |
| Match of the Day begins on BBC One* | 10:30pm |
| Highlights on LCFC.com | 12pm (Monday) |
*United Kingdom only.
Who's in contention to play?
"Jamie Vardy will be out for a few weeks," Brendan Rodgers told the media on Friday. "As you know, we’ve been managing him over this last number of months, and he’s been absolutely fantastic. We have a window now that allows him to have a minor operation on his hernia and then he’ll be back within a few weeks. He’ll be out for that period. Obviously, Dennis Praet has been away, and Wes Morgan will be out for a few weeks as well, but apart from that, we have the same squad."
What happened last time?
Kelechi Iheanacho's early close-range effort, following excellent inter-play between James Justin and Dennis Praet, gave Leicester City a narrow 1-0 win at Brentford in the FA Cup Fourth Round on 25 January, 2020.
In the final FA Cup tie to ever be staged at Brentford's old Griffin Park ground, Academy graduate Kiernan Dewsbury-Hall also came off the bench for the Foxes to make his senior debut for the Club.
When can I catch match highlights?
Match highlights can be accessed on LCFC.com from midday the day following Emirates FA Cup ties - available for free to Digital Members on the Club's official website (free sign-up), while short clips will also be found on Leicester City's official social media channels.
Please note that in the interests of safety, Leicester City’s fixtures will continue to be played behind closed doors. To ensure matches can still go ahead and to help control the spread of COVID-19, the Football Club kindly asks its supporters to continue to follow their team from home and not to gather at any stadia.
All times GMT unless stated otherwise.