The Foxes are unbeaten against the Red Devils this term after drawing 2-2 in the league back in December, before securing a 3-1 win over Ole Gunnar Solskjær's men in the quarter-finals of the Emirates FA Cup earlier in 2021.
Ahead of Tuesday's encounter in the North West, LCFC.com has all you need to know...
How can I watch the game?
Supporters based in the United Kingdom can watch the action unfold on BT Sport 1 from 5:30pm on Tuesday. Elsewhere around the world, meanwhile, the international Blue Army can use the following TV stations...
| Country | Channel | Local time |
| Australia | Optus Sport | 4am (Wednesday) |
| Belgium | Play Sports & Voo Sports | 7pm |
| Brazil | ESPN | 12pm |
| Canada | DAZN | 12pm |
| China | Tencent Sports | 1am (Wednesday) |
| Denmark | Xee | 7pm |
| Egypt | beIN Sports | 7pm |
| France | RMC & Canal+ | 7pm |
| Germany | Sky Sports | 8pm |
| Hong Kong | NOW | 2am (Wednesday) |
| India | Disney+ Hotstar & Select | 10:30pm |
| Japan | DAZN | 2am (Wednesday) |
| Mexico | Sky Sports | 1pm |
| New Zealand | Spark Sport | 6am (Wednesday) |
| South Africa | Super Sport | 7pm |
| Thailand | truevisions | 12am (Wednesday) |
| United States | NBC | 1pm |
Can't see your country? Click HERE for the full schedule.
Who's starring on LCFC TV?
From 4:30pm on Tuesday, presenter Dan Bates will be joined by Matt Elliott and Iwan Roberts for 90 minutes of pre-match discussion, while fellow former Fox Gerry Taggart will dial in from the pressbox at Old Trafford to provide his preview too.
Matchday Live is the first place to find confirmed starting line-ups for both teams at 5pm before, from around 5:50pm, live commentary begins 10 minutes ahead of kick-off in Manchester, as Leicester go in search of another vital three points in the Premier League.
While pre and post-match coverage can also be found on @LCFC social media channels, in-play commentary is exclusive to the dedicated LCFC.com Match Centre, where you can also enjoy live text updates and photography from the Theatre of Dreams.
After the game, meanwhile, Elliott, Roberts and Taggart stay on air for another half an hour to reflect on what is sure to be a dramatic outing for the Foxes against the 20-time English champions on matchday 36.
What's the officiating team?
Craig Pawson will oversee matters on Tuesday, assisted by Ian Hussin and Richard West. The fourth official is Mike Dean, while Jonathan Moss is on VAR duties, alongside Marc Perry.
When does everything happen?
City are due in Manchester on Tuesday evening - and here's when everything happens...
| Event | Time |
| Matchday Live begins on LCFC TV | 4:30pm |
| Team news confirmed on @LCFC social media | 5pm |
| BT Sport coverage commences* | 5:30pm |
| Commentary starts on LCFC Radio | 5:50pm |
| Kick-off | 6pm |
| Full-time | 7:45pm approx |
| Short highlights on LCFC TV | 9:45pm approx |
| Full highlights on LCFC TV | 12am (Wednesday) |
*UK only.
What's the injury news?
"We've been managing him over the last couple of weeks and he's come through really well," Brendan Rodgers said, on Jonny Evans' condition. "He was in a lot of pain [last Thursday] and woke up [on Friday] feeling better. In the warm-up, just as he was coming in before kick-off, he felt discomfort.
"Jonny's a real warrior so you know if he's not able to at least give it a go, then he's really suffering. We'll just have to see how he is and what his availability is going forward."
What happened last time?
The two sides played out an entertaining 2-2 draw in the league fixture held at King Power Stadium on Boxing Day 2020. The visitors twice went ahead via goals from Marcus Rashford and Bruno Fernandes, though the Foxes fought back through Harvey Barnes' effort and a late own goal from Axel Tuanzebe.
The Foxes also secured a memorable Emirates FA Cup Quarter-Final triumph over the Red Devils in March. A brace from Kelechi Iheanacho and Youri Tielemans' strike sent City into the last four of the competition.
When can I catch match highlights?
A two-minute highlights package will be available for supporters to access on LCFC TV approximately two hours after full-time, which is available for free to Digital Members on the Club's official website (free sign-up).
A full highlights video will be published on LCFC.com at midnight following the fixture and Leicester City's official social media channels will post short clips from the day's action.
Please note that in the interests of safety, Leicester City’s fixtures will continue to be played behind closed doors. To ensure matches can still go ahead and to help control the spread of COVID-19, the Football Club kindly asks its supporters to continue to follow their team from home and not to gather at any stadia.
All times BST unless stated otherwise.