The Foxes have won their last two matches in all competitions, dispatching Legia Warsaw in the UEFA Europa League, before Sunday's 4-2 success over Watford at a snowy King Power Stadium. The Saints, meanwhile, have lost their last two - against Norwich City and Liverpool.
In April, when City last visited the south coast, James Ward-Prowse and Jonny Evans found the net in a 1-1 draw between the sides, although Leicester did enjoy a 2-0 success at home in the league, plus a one-goal victory in the semi-finals of the Emirates FA Cup.
Ahead of Wednesday's clash, LCFC.com has all the key details...
Who's starring on LCFC Radio?
Supporters will be able to tune in to Matchday Live from 6pm on Wednesday evening, when a trio of Foxes legends help guide you through the action.
Gerry Taggart and Iwan Roberts are set to join presenter Dan Bates in the studio as part of a one-and-a-half-hour preview show beginning 90 minutes prior to kick-off, broadcast live and for free on both LCFC.com and @LCFC social media.
Matt Elliott, positioned in the pressbox at St. Mary’s, will also form part of the pre-match analysis and debate before being joined by commentator Chris Parrott, from approximately 7:20pm, to provide match updates as they happen.
The Blue Army can listen to it all unfold for free, with LCFC Radio’s in-play commentary only available via the dedicated LCFC.com Match Centre.
Following full-time, Roberts, Taggart and Elliott will all be on hand to offer their post-match thoughts on proceedings during a further 30 minutes of broadcasting – which can be accessed on social media, while highlights will be available later that evening on LCFC TV.
What's the officiating team?
Referee Robert Jones will be assisted by Eddie Smart and Derek Eaton on Wednesday, while the fourth official is Simon Hooper. VAR is overseen by Andy Madley and assistant Adrian Holmes.
When does everything happen?
All the key matchday timings for Leicester City’s latest top-flight away fixture...
| Event | Time |
| Matchday Live begins | 6pm |
| Team news announced on @LCFC | 6:30pm |
| Coverage starts on Amazon Prime Video* | 6:30pm |
| Kick-off | 7:30pm |
| Full-time | 9:20pm approx |
| Match of the Day on BBC One* | 10:35pm |
| Two-minute goals video on LCFC TV | 11:20pm approx |
| Short highlights and clips available on @LCFC | 12am (Thursday) |
| Full highlights on LCFC TV | 12am (Thursday) |
*UK only.
What happened last time against the Saints?
Ten-man Southampton held Leicester City to a 1-1 draw at St. Mary's Stadium on 30 April, despite losing Jannik Vestergaard after just 10 minutes. James Ward-Prowse in fact put the Saints ahead from the penalty spot despite City's dominance on the south coast.
Jonny Evans' header rescued a point for the Foxes, though, as goalkeeper Alex McCarthy made a string of impressive saves to frustrate the visitors.
When can I catch match highlights?
A short highlights package is set to be published on LCFC.com two hours after full-time, at approximately 11:20pm on Thursday evening, followed by extended match highlights being available to watch on the Club's official website from midnight on Thursday. Short clips and highlights will also be posted on Leicester City's official social media channels at the same time (12am).
All times GMT unless stated otherwise.