Remaining level on aggregate, the second leg, an 8pm kick-off against the Italian giants managed by José Mourinho will determine who plays Marseille or Feyenoord in the inaugural competition’s showpiece event in Tirana.
A comprehensive supporter guide for fans travelling to the match can be found here.
Prior to kick-off in Rome, here’s the lowdown on the crucial tie, featuring timings, key information and the story so far…
Who's starring on LCFC TV?
Build-up to Thursday’s 8pm kick-off will begin at 6:30pm when Matchday Live gets underway from the studio, as presenter Lewis Mason is joined by Foxes legends Iwan Roberts and Gerry Taggart.
Available to watch on @LCFC social media, the one-and-a-half-hour preview show, which includes interviews from both camps, will also feature contributions from another former City star Matt Elliott, who will be out in Rome.
Then, at around 7:50pm, LCFC Radio commentary begins, with Elliott positioned in the pressbox alongside Dan Bates and Niall McCaughan for live updates from Italy – exclusively available for free on the dedicated Match Centre.
After the full-time whistle blows, a further 30 minutes of analysis and debate will follow on LCFC's digital radio station, with reaction to what could be another historic night in Leicester City’s latest European journey.
What's the officiating team?
Serbian referee Srdjan Jovanović will take charge of the encounter, assisted by his compatriots Uroš Stojković and Milan Mihajlović. Orel Grinfeeld of Israel is set to be the fourth official in Rome.
VAR, introduced in the competition for the semi-finals onwards, will be operated by Bastian Dankert, with Marco Fritz, also from Germany, as his assistant.
What happened last time against Roma?
Filbert Way hosted an enthralling first leg which saw Lorenzo Pellegrini fire the visitors into an early lead, before Gianluca Mancini’s own goal levelled the scores, how it stayed after 90 minutes in Leicester last Thursday.
When does everything happen?
This European matchday timetable guides you through the evening’s events…
| Event | Time |
| Matchday Live begins on LCFC TV | 6:30pm |
| Team news confirmed on @LCFC social media | 6:30pm approx |
| BT Sport 3 coverage starts* | 7:15pm |
| Live commentary underway on LCFC Radio | 7:50pm approx |
| Kick-off | 8pm |
| Full-time | 9:50pm approx |
| Short highlights on LCFC.com | 12am (Friday) |
| Full highlights on LCFC.com | 12am (Saturday) |
* United Kingdom only.
When can I catch match highlights?
Supporters will be able to access a short highlights package on LCFC TV after midnight on Friday, about two hours after full-time at Stadio Olimpico.
Extended highlights will then be available via the Club's official website after midnight (12am) on Saturday, with goals and short social clips published on @LCFC social channels from the same time.
Digital content can be accessed by signing in for free as a Digital Member.
All times BST.