Ahead of that encounter on the south coast, LCFC.com has crunched some of the numbers...
Last league encounter
Leicester City 1 Southampton 2
Premier League
King Power Stadium
20/08/2022
Maddison / Adams (2)
Last FA Cup encounter
Leicester City 1 Southampton 0
Semi-Final
Wembley Stadium
18/04/2021
Iheanacho
Last League Cup encounter
Leicester City 0 Southampton 0 (6-5 on pens)
Fourth Round
King Power Stadium
27/11/2018
The last time
Last Leicester City hat-trick: Ayoze Pérez & Jamie Vardy | 25/10/2019 | Premier League | St. Mary's Stadium
Last Southampton hat-trick: Matt Le Tissier | 07/03/1987 | First Division | The Dell
Leicester City post-war hat tricks: Ayoze Pérez, Jamie Vardy
Southampton post-war hat tricks: Charlie Wayman, Ron Davies, Matt Le Tissier
Last Leicester City penalty scored: Jamie Vardy | 25/10/2019 | Premier League | St. Mary's Stadium
Last Southampton penalty scored: James Ward-Prowse | 22/05/2022 | Premier League | King Power Stadium
Leicester City post-war penalties: Arthur Rowley, Jackie Sinclair, David Nish, Jon Sammels, Steve Lynex (3), Garry Parker, Paul Dickov, Jamie Vardy
Southampton post-war penalties: Ernie Stevenson, Graham Baker, Kevin Bond, Matt Le Tissier, Marian Pahars, Andrew Surman, Dusan Tadic, James Ward-Prowse (3)
Last Leicester City own goal conceded: John Sjoberg | 09/09/1970 | League Cup Second Round | Filbert Street
Last Southampton own conceded: Rickie Lambert | 27/08/2011 | Championship | King Power Stadium
Leicester City post-war own goals: John Sjoberg
Southampton post-war own goals: Bert Elliott, Richard Dryden, Rickie Lambert
Last Leicester City debutant: Danny Drinkwater, Nathan Delfouneso | 23/01/2012 | Championship | St. Mary's Stadium
Last Southampton debutant: Yan Valery | 27/11/2018 | League Cup Fourth Round | King Power Stadium
Leicester City post-war debutants: Ted Jelly, Malcolm Manley, Tommy Christensen, Paul Reid, Junior Lewis, Brian Deane, Martin Reeves, John Curtis, Ben Thatcher, Keith Gillespie, Lilian Nalis, Les Ferdinand, Riccardo Scimeca, Nikos Dabizas, Ricky Sappleton, Danny Drinkwater, Nathan Delfouneso
Southampton post-war debutants: Len Wilkins, Walter Judd, Pat Parker, Gerry Gurr, Mark Dennis, Graham Potter, Dani Ferreira Rodrigues, Graeme Le Saux, Neil McCann, Kevin Phillips, Jim Brennan, Darren Potter, Simon Gillett, Yago Falque, Yan Valery
Last Leicester City player sent off: None
Last Southampton player sent off: 30/04/2021, Premier League, St. Mary's Stadium, Jannik Vestergaard
All Leicester City dismissals: None
All Southampton dismissals: Barry Venison, Kevin Davies, Dean Richards, Pierre-Emile Højbjerg, Yan Valery, Ryan Bertrand, Jannik Vestergaard
Last transfer to Leicester City: Jannik Vestergaard | 13/08/2021 | Undisclosed
Last transfer to Southampton: Dany N'Guessan | 26/01/2011 | Loan
Other players who have represented both clubs include: Ian Andrews, Ryan Bertrand, David Connolly, Mark Draper, Nathan Dyer, Tim Flowers, Dean Hammond, Trevor Hebberd, Kasey Keller, Darren Kenton, Tony Knapp, Dave Maclaren, Chris Makin, Matt Mills, Steve Moran, Matt Oakley, Russell Osman, Kevin Phillips, Peter Rodrigues, Dennis Rofe, Tony Sealy, Peter Shilton, Ryan Smith, David Speedie, Stuart Taylor, Dave Webb, Ian White, Dennis Wise and Frank Worthington
Leading Leicester City goalscorer vs. Southampton: Jamie Vardy | 6
Leading Southampton goalscorer vs. Leicester City: Charlie Wayman | 10