The Under-23s have made a magnificent start to their Premier League 2 campaign, sitting fourth in the early standings, but lost 3-0 to Fleetwood Town last month in the EFL Trophy.
City, one of 16 clubs to have been invited to enter a side into the competition, have been placed alongside Fleetwood Town, Carlisle and Morecambe in Northern Group A.
Ahead of the 7:45pm kick-off at Brunton Park on Tuesday night, here are five things you need to know…
Carlisle in focus
Carlisle got back to winning ways at the weekend with a 1-0 success over Crawley Town in Sky Bet League 2, courtesy of Hallam Hope's first-half header.
Keith Curle's Cumbrians sit 14th in the fourth tier with four wins, two draws and five loses to their name so far this season.
Meanwhile, following a 2-0 victory over Morecame in August, Carlisle will also be looking for their second success in the Checkatrade Trophy on Tuesday evening.
Last time out
City sparkled at King Power Stadium on Wednesday to open the Premier League International Cup with a 3-0 success over Hertha Berlin.
In front of the Blue Army on Filbert Way, defender Sam Hughes gave the Foxes the lead inside 120 seconds before Darnell Johnson and Admiral Muskwe made sure of the result.
It was the latest impressive result from the Under-23s, who have already defeated PL2 champions Everton and FA Youth Cup holders Chelsea this term.
Hughes loving life at City
After scoring his first goal for the Foxes on Wednesday evening, centre back Hughes says he is enjoying his football at the Club this season.
He told LCFC TV: “It was always going to be different for me, coming from Chester. I’ve been adapting to the tactical side of it.
“I’m loving it here, I’m fortunate that I’m playing. I’ll just keep putting in good performances and try to keep my place in the team.”
Petty’s thoughts
Development Squad coach Ben Petty has looked ahead to the clash at Brunton Park, saying he expects another considerable challenge for the Club’s young stars.
“It will be a test. We will be without our four international players [Johnson, George Thomas, Alex Pascanu and Daniel Iversen], so it enables other lads to come into the team.”
On the Hertha result, he added: “This International Cup allows you to pay at the stadiums against foreign opposition and we have all enjoyed it. We’re delighted with their progress.”
Tickets and travel
Supporters can attend the fixture in Carlisle for £10 for Adults and £5 for Seniors and Young Persons...
Adults - £10
Seniors (Over-65s) - £5
Young Persons (18-22) - £5
Juniors (11-17) £5
Child Under-11s - £1
Child Under-7s – FREE
Supporters with disabilities (wheelchair) - £2
Ambulant carers – FREE
Carlisle ticket office contact: 0844 371 1921. Please note that calls cost 7p per minute from landlines and mobile charges may vary.
Admission to the ground is by ticket only. Fans arriving on the day can purchase a ticket from the main ticket office on the west side of the ground from 5:30pm.
For more information, click HERE.